Ron Zacapa Centenario is a premium rum produced in Guatemala by Rum Creation and Products, a subsidiary of Industrias Licoreras de Guatemala, and distributed and marketed by Diageo. Zacapa Centenario was created in 1976 to celebrate the hundredth anniversary of the foundation of Zacapa, a town in eastern Guatemala.

It was the result of the blending, stabilization and maturing processes of long-aged rums by doctor and chemist named Alejandro Burgaleta. Ron Zacapa is distinctive in that it is aged in a facility at an altitude with natural coolness which avoids evaporation resulting in an unusually smooth product.